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Definition of louse noun from the Oxford Advanced Learner's Dictionary

louse

noun
 
/laʊs/
 
/laʊs/
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  1. (plural lice
     
    /laɪs/
     
    /laɪs/
    )
     a small insect that lives on the bodies of humans and animals
    • head lice
    see also nit, woodlouseTopics Insects, worms, etc.c2
  2. (plural louses)
     (informal, disapproving) a very unpleasant person
    • Steve had let her down; she should never have trusted the louse.
    3. Word OriginOld English lūs, (plural) lȳs, of Germanic origin; related to Dutch luis, German Laus.
See louse in the Oxford Advanced American Dictionary
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